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The main use and source of calcium pantothenate

Oct. 10, 2019

Calcium pantothenate is easily soluble in water and glycerin and insoluble in alcohol, chloroform and ether. Used in pharmaceutical, food and feed additives. It is a component of Coenzyme A, which is involved in the metabolism of carbohydrates, fats and proteins. It is clinically used to treat vitamin B deficiency, peripheral neuritis, and postoperative intestinal colic.

The main application of calcium pantothenate is in pharmaceutical, food and feed additives. It is a component of Coenzyme A, which is involved in the metabolism of carbohydrates, fats and proteins. It is an indispensable trace substance for humans and animals to maintain normal physiological functions. More than 70% is used as a feed additive.

For the treatment of vitamin B deficiency, peripheral neuritis, postoperative intestinal colic. Participate in the metabolism of proteins, fats and sugars in the body.

The preparation method or source of calcium pantothenate is as follows

It is obtained by using methyl isobutyraldehyde or the like as a raw material by methylolation, addition, hydrolysis, acidification, lactonization or acylation.

Put formaldehyde and anhydrous potassium carbonate into the reaction pot, add isobutyraldehyde at 14-20 ° C, stir the reaction for 3 h after the addition, and then let stand for 0.5 h at 14-18 ° C to obtain the upper oil 2, 2 - Dimethyl-3-hydroxypropanal.

2,2-dimethyl-3-hydroxypropanal is dissolved in 4 times of water, sodium cyanide is dissolved in 6 times of water, calcium chloride is dissolved in 2 times of water, and the above solution is sequentially added to the reaction pot. Add 50% sulfuric acid solution under stirring, react at 60-65 ° C for 6 h, then warm to 80-85 ° C for 3 h, concentrate under reduced pressure until thick, add 95% ethanol to precipitate inorganic salt, filtrate After recovering ethanol by distillation under reduced pressure, a fraction of 130-145 ° C (1.33 - 2.39 KPa), i.e., γ-butyrolactone, was collected.

β-Aminopropionic acid, 5/6 methanol and lime were sequentially added to the reactor, the temperature was raised to 40 ° C, and the reaction was stirred for 2 h. After the reaction solution was allowed to stand, the supernatant was subjected to hydraulic filtration. The solid residue in the pot was washed with 1/6 methanol and then filtered. The filtrate was placed in another reaction pot, and γ-butyrolactone was added thereto to stir and dissolve, and the mixture was allowed to stand at room temperature for 40 hours to form calcium pantothenate. After stirring with water, the mixture was cooled to -5-0 ° C, and crystallized by adding seed crystals for 24 hours, and filtered to obtain racemic calcium pantothenate.

Put 2/3 amount of racemic calcium pantothenate and calcium levothate into the reaction pot, add methanol and water, heat to 40 ° C, stir to dissolve, and filter while hot, the filtrate is cooled to 15 ° C, add a small amount of L-Pantactite calcium seed crystal, Crystal 2h. When the specific optical rotation is +6°-+8°, the crystals are separated and washed with a small amount of methanol to obtain calcium L-pantothenate (still used for resolution). The remaining 1/3 of the racemic calcium pantothenate was stirred and dissolved in a filtrate of 35-40 ° C, filtered, cooled to 15 ° C, and a small amount of calcium dextran pantothenate seed crystal was added and incubated for 2 h. The crystals were separated when the specific optical rotation was -0.8 ° - -0.6 °, washed with a small amount of methanol, and dried under vacuum to obtain calcium dextran.

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