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Introduction to 4-Chlorobenzotrichloride - haihang industry

May. 30, 2019

4-Chlorobenzotrichloride (PCBTF), colorless transparent liquid, insoluble in water, soluble in organic solvents such as alcohol, ether, benzene, flammable, toxic chemicals, irritating to skin and eyes, in case of fire, high heat or Contact with oxidant can burn and emit toxic gases. The main use is intermediates for the production of pharmaceuticals, pesticides and dyes.

Main use of 4-Chlorobenzotrichloride

It is used in the synthesis of pharmaceutical trifluralin, difludroxil, pesticide fluoroester valerian, flufenacetate, and fluorofluoroether herbicide; in addition, it can also be used in the dye industry.

Method for producing 4-Chlorobenzotrichloride

Photochlorination, liquid phase fluorination with p-chlorotoluene via side chain

Chlorination: P-chlorotoluene is introduced into a photochlorination reactor, heated to 120-150 ° C, and subjected to chlorine reaction under irradiation with a fluorescent lamp. A small amount of the reaction solution was taken every 10-15 minutes for gas chromatography analysis. The reaction was stopped when the p-chlorotrichlorotoluene content was greater than 90%. The product was distilled under reduced pressure to give p-chlorotrichlorotoluene. The yield is 90-95%.

Fluorination: Put p-chlorotrichlorotoluene into the fluorination reactor, and add 4-5 times of anhydrous hydrogen fluoride to the molar ratio. After the temperature rise, the reaction is carried out at 1.9-2.4 MPa until the reaction pressure no longer rises. The hydrogen chloride gas evolved during the reaction is absorbed by the alkali, and the reactant is neutralized and steam distilled to obtain a crude product. The distillation was then repeated to obtain a p-chlorotrifluorotoluene liquid having a boiling range of 138-140 °C. The yield is 80-90%.

Toxicity and environmental impact of 4-Chlorobenzotrichloride

It has a stimulating effect on the skin, mucous membranes and upper respiratory tract. High concentration has a strong damage to the eyes, mucous membranes and upper respiratory tract. Contact can cause burning sensation, cough, wheezing, laryngitis, shortness of breath, headache, nausea and vomiting. Prolonged exposure can cause lung irritation, chest pain, pulmonary edema . It is harmful to the environment and may cause pollution to water bodies.

Packaging, transportation and storage

The galvanized iron drum is sealed and packaged. The storage warehouse should be cool, shelter from the rain and avoid exposure to the sun. It is well ventilated and dry. It is transported according to flammable and explosive toxic chemicals. It is strictly prohibited to mix and transport with oxidants and food.

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